Alex Hughes claimed career-best figures of 4-46 as Derbyshire enjoyed the better of the opening day against Glamorgan at The 3aaa County Ground.
Tony Palladino (3-14) took three early wickets, before Hughes, Mark Footitt (2-37) and Tom Taylor (1-30) removed the remaining Glamorgan batsmen to dismiss the visitors for 138 just before Tea.
Wes Durston (50) hit a run-a-ball fifty and opener Ben Slater hit 40, but late wickets pegged back the hosts' reply as Derbyshire closed on 142-6, a lead of four runs after Day One.
It was a good toss to win for Captain Wayne Madsen, as an excellent opening spell from Palladino left Glamorgan reeling on 13-3. The right-arm paceman took three wickets for only seven runs in his eight over stint.
All-rounder Hughes took the first of his career-best haul when he had Cooke lbw for 11, to break the 20-run partnership with Murray Goodwin shortly before Lunch.
19-year-old Academy product Taylor took the final wicket before Lunch, enticing the edge of Jim Allenby (14) through to Gareth Cross, who claimed his 200th dismissal in first-class cricket, with Glamorgan 50-5.
The partnership for the sixth Glamorgan wicket frustrated Derbyshire initially after Lunch, but Hughes found the edge of Goodwin for 44.
The remaining four wickets, however, were taken for only 24 runs as the visitors were all out for 138.
Hughes removed James Harris (6) and the final wicket of Dean Cosker (1) to return career-best figures of 4-46 off his 12.2 overs.
Slater and Billy Godleman added 23 for the first wicket, before Godleman was first man out for 10.
Madsen fell lbw to Allenby for 18 after having batting well, before Shivnarine Chanderpaul was out lbw to Owen for three to leave Derbyshire on 63-3.
Wes Durston responded, however, to hit his third half-century off the campaign. He struck 50 from just 57, including six fours and a six, to propel his side past a hundred before being caught behind off Harris.
Slater produced a solid innings to hit 40 off 107 balls (5 fours), but he fell shortly before the close. There was still time for the hosts to also lose night-watchmen Taylor (0), but Derbyshire ended the day on 142-6 and lead by six runs.
Graeme Welch said: “The lads are bowling well in tandem and the unit is coming on. You can get carried away on pitches like this but they bowled good lines and good lengths and got their rewards.
"If we had been four down it would probably have been our day but we’ve just let them back in with another couple of wickets.”
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